Dehydroepiandrosterone (DHEA): Medical Uses, Side Effects and Interactions

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Dehydroepiandrosterone (DHEA) is a hormone that is naturally synthesized by a body. It performs a series of roles and has been investigated widely for a intensity healing effects in a operation of conditions.1

Referred to by some as “the mom of all hormones,” a “super hormone” and a “fountain of girl hormone,” a law behind DHEA is many some-more difficult and presents a horde of unanswered questions.

DHEA is underneath review for use in a sundry preference of conditions including lupus, depression, adrenal insufficiency, cervical cancer, vaginal atrophy and weight loss.

The actions of DHEA are complex, though a hormone does uncover guarantee in a diagnosis of some illnesses. In this article, we will demeanour during a functions of DHEA, what it does in a brain, some of a conditions it is being used to treat, compared interactions, contraindications and side effects of a use.

What is dehydroepiandrosterone (DHEA)?

DHEA is also famous as androstenolone, 3β-hydroxyandrost-5-en-17-one and 5-androsten-3β-ol-17-one. It is an endogenous steroid hormone; in other words, it is naturally synthesized by a physique and acts on specific tissues or cells, spurring them into action.

DHEA is an endogenous steroid hormone, naturally synthesized by a body.

DHEA is a many abounding steroid hormone in a tellurian physique and is constructed by a adrenal glands, gonads and brain. In normal circumstances, DHEA is many ordinarily found in a form of dehydroepiandrosterone sulfate (DHEAS).

The primary purpose of DHEA is as an surrogate proton in a singularity of estrogen and androgen sex hormones.

Among other things, DHEA is concerned in building supposed androgenic effects, also referred to as masculinization. These changes embody a prolongation of oilier skin, changes in physique fragrance and a expansion of armpit and pubic hair.

Other than this surrogate role, DHEA also plays a partial in other physiological pathways; it binds to a series of receptor forms and is famous to act as a neurosteroid, directly inspiring neuronal excitability.

Some cruise DHEA to raise jaunty opening and, nonetheless justification is scant, a World Anti-Doping Agency has deemed it a taboo piece underneath a World Anti-Doping Code.2

A tiny series of athletes have perceived foe bans for holding DHEA.3

Production of DHEA peaks between a ages of 20 and 40, and declines from this indicate onwards. This is a categorical reason that DHEA is deliberate an critical chemical in a aging process, and a intensity aim for anti-aging drugs.4

Wild yam and soy enclose chemicals that can be converted into DHEA in a laboratory. However, a physique can't modify them in a same way; as a result, eating soy or yams will not boost DHEA levels.

Although investigate into DHEA has increasing in new years, a good series of questions about a hormone sojourn unanswered, quite per a ways in that it mediates a effects and a activity in a brain.

DHEA’s purpose in a brain

As mentioned above, DHEA acts as a neurosteroid, directly behaving on targets within a brain. Its activities are not entirely understood, though some researchers trust DHEA is concerned in safeguarding neurons from toxins and after injuries such as strokes. Some investigate also suggests that DHEA competence have a purpose in haughtiness growth, shortening inflammation and preventing dungeon death.5

In some circumstances, DHEA appears to allay mood and, for that reason, it has been trialed for a diagnosis of mood disorders such as stress and depression.

Research published in a biography Nature in 2013 found that DHEA extended connectors between a amygdala and hippocampus and reduced activity levels in both regions. These changes are suspicion to be compared with both improvements in mood and a reduced memory for romantic events.6

Some studies have found that naturally aloft levels of DHEA and DHEAS have a certain outcome on some forms of cognitive tasks. For instance, a investigate of women aged 21-77 found that:

“Higher endogenous DHEAS levels are exclusively and agreeably compared with executive function, concentration, and operative memory.”7

Similar experiments have had paradoxical or conflicting findings, however. Fully bargain DHEA’s purpose in a mind stays a challenge.

Naturally lifting DHEA levels

DHEA can be increasing naturally in certain circumstances. Under caloric restriction, for example, DHEA quantities increase. This is one of a hypothesized mechanisms behind a speculation that caloric limitation competence boost lifespan.8

Regular practice also raises a body’s healthy outlay of DHEA.


On a subsequent page, we demeanour during DHEA’s medical uses and side effects.

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